Muscle first in neurodegenerative disease?

Astrocytes in neurodegenerative disease.

Astrocytes contribute to the maintenance of the health and function of the central nervous system (CNS). Thus, it is not surprising that these multifunctional cells have been implicated in the onset and progression of several neurodegenerative diseases. The involvement of astrocytes in the neuropathology of these diseases is likely a consequence of both the loss of normal homeostatic functions ...

Bioinformatics in Neurodegenerative Disease

The brain response to the original viral insult is a crucial aspect of the pathogenesis of AIDS dementia. The study of host gene expression in HIV-1 associated brain disease will facilitate establishing new paradigms and mechanisms for pathogenesis. HIV with only 9 genes is able to destroy its host with more than 30,000 genes. We used gene chip technology (Affymetrix) of brain tissue from AIDS ...

Neurodegenerative Disease Parkinson’s Disease

Oral levodopa remains the most effective symptomatic drug for Parkinson’s disease (PD); however, its long-term use is limited by the emergence of motor fluctuations and involuntary movements, particularly in young-onset patients. A growing number of pre-clinical and clinical studies suggest that non-physiological pulsatile stimulation of striatal dopamine (DA) receptors induced by the use of sh...

First report of Johne's disease in Iran

Antibody therapy in neurodegenerative disease.

Advances in medical science have led to increased life expectancy and increased median age in the population. Because the symptoms of neurodegenerative diseases generally onset in mid- to late-life, a concomitant increase in the number of persons afflicted with these devastating diseases has occurred. Developing therapies for neurodegenerative diseases is of the highest priority due to the enor...